Fatal aluminium phosphide poisoning due to myocardial depression refractory to high dose inotropic support and intra-aortic balloon counterpulsation
نویسندگان
چکیده
We report a case of aluminium phosphide poisoning that presented to us with refractory myocardial depression. This patient developed worsening circulatory failure that did not respond to inotropic or vasopressor support and intra-aortic balloon counterpulsation. She went on to develop progressive metabolic acidosis, renal failure and died within 48 hours of admission to the intensive care unit.
منابع مشابه
Successful treatment of cardiogenic shock with an intraaortic balloon pump following aluminium phosphide poisoning.
Aluminium phosphide (AlP) is a highly toxic pesticide that inhibits cytochrome oxidase c and causes oxidative stress. Death results from refractory cardiogenic shock due to myocardial dysfunction. There is very little information regarding extracorporeal life support in severe AlP poisoning. Although several therapies are available, none are curative. We report on the use of an intra-aortic bal...
متن کاملTreatment Options in Cardiogenic Shock with Intra-aortic Balloon Counterpulsation
Cardiogenic shock (CS), a state of inadequate tissue perfusion due to cardiac dysfunction, remains the leading cause of death following acute myocardial infarction (AMI). While the prognosis of CS post-AMI has improved in recent decades due to advances in treatment modalities, the mortality rates remain unacceptably high (~40–50% according to recent registries and clinical trials). Current trea...
متن کاملUsing Intra-Aortic Balloon Pump for Management of Cardiogenic Shock Following Aluminum Phosphide Poisoning; Report of 3 Cases
Introduction Aluminium phosphide (Alp) poisoning mortality rate has been reported as high as 70-100%, and refractory hypotension and cardiogenic shock are the two most common presentations leading to death. Due to lack of specific antidote, all treatments are focused on supportive care and recently, intra-aortic balloon pump (IABP) has been suggested to treat cardiogenic shock resulting from to...
متن کاملSuccessful Treatment of Aluminium Phosphide Poisoning: A Case Report
Aluminium phosphide (AlP) is used to kill rodents in grain storage. It produces phosphine gas which is toxic for mitochondria. The exact mechanism of action is unclear, but phosphine is thought to produce toxicity by blocking cytochrome-c oxidase, which inhibits oxidative phosphorylation and result in cell death. This poisoning has a high mortality, and survival is unlikely if more than 1.5 g i...
متن کاملIs Intra-Aortic Balloon Pump Counterpulsation Sufficient to Treat Patients in Cardiogenic Shock, Undergoing Primary Percutaneous Coronary Intervention
BACKGROUND A high number of patients do not survive primary percutaneous coronary intervention (PCI) complicated by cardiogenic shock (CS), even when assisted with intra-aortic balloon pump (IABP) counterpulsation. There is no accepted consensus on who may most benefit from IABP counterpulsation, although previous retrospective studies have reported predictors of survival for patients undergoin...
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2008